QSC Peptides · ≥99% purity
Anavar (Oxandrolone) is a DHT-derived oral AAS with a 322:24 anabolic:androgenic ratio — among the highest anabolic selectivity of any AAS. Does not aromatize. Relatively low hepatotoxicity vs other C17α-AA orals. QSC Peptides offers Anavar 50mg tablets — ≥99% purity, free USA shipping.
Anavar (Oxandrolone) is a synthetic DHT derivative with a modified A-ring — an oxygen atom replaces the C2 carbon, creating a 2-oxa modification. This distinguishes oxandrolone from other DHT derivatives and contributes to its unique receptor binding profile and anabolic selectivity.
As a DHT derivative, oxandrolone cannot be aromatized (no C-19 position pathway) and cannot undergo further 5α-reduction (already at the 5α-reduced DHT level). It binds AR with ~0.6× the affinity of testosterone, but the 322:24 ratio indicates highly tissue-selective anabolic activity — particularly strong in muscle relative to androgenic tissues.
Oxandrolone's selectivity comes from tissue-specific differences in its AR transactivation profile. In androgen-sensitive tissues like prostate and skin, oxandrolone shows relatively weak activity. In skeletal muscle, it drives protein synthesis through AR-mediated gene programs with high efficiency. The 2-oxa modification may contribute to this tissue selectivity through altered coactivator recruitment.
All C17α-alkylated oral AAS are hepatotoxic to varying degrees. Oxandrolone is considered relatively mild compared to Dianabol and Anadrol due to its predominantly renal excretion (unlike other 17α-AA which undergo extensive hepatic processing), but hepatic monitoring remains relevant in liver research models.
Research-grade · ≥99% purity · COA · Free USA USPS/FedEx · US domestic warehouse
QSC Peptides · ≥99% purity