// Oxandrolone · DHT Derivative · 322:24 Ratio · No Aromatization · Liver-Mild

AnavarOxandrolone — DHT Oral AAS Research Reference by QSC Peptides

Anavar (Oxandrolone) is a DHT-derived oral AAS with a 322:24 anabolic:androgenic ratio — among the highest anabolic selectivity of any AAS. Does not aromatize. Relatively low hepatotoxicity vs other C17α-AA orals. QSC Peptides offers Anavar 50mg tablets — ≥99% purity, free USA shipping.

Compound Profile

Parent StructureDHT (dihydrotestosterone)
Anabolic:Androgenic322:24
AR Binding~0.6× testosterone
AromatizationNone
5α-ReductionDHT derivative (no further)
C17α AlkylationYes (oral)
Half-Life~9 hours
HepatotoxicityRelatively low (C17AA)
QSC Purity≥99%
Vial Size50mg tablets
QSC Peptides ≥99% Purity Verified COA Every Order Free USA USPS/FedEx US Domestic Stock 8 Warehouse Regions
// Mechanism of Action

How Anavar Works

Anavar (Oxandrolone) is a synthetic DHT derivative with a modified A-ring — an oxygen atom replaces the C2 carbon, creating a 2-oxa modification. This distinguishes oxandrolone from other DHT derivatives and contributes to its unique receptor binding profile and anabolic selectivity.

As a DHT derivative, oxandrolone cannot be aromatized (no C-19 position pathway) and cannot undergo further 5α-reduction (already at the 5α-reduced DHT level). It binds AR with ~0.6× the affinity of testosterone, but the 322:24 ratio indicates highly tissue-selective anabolic activity — particularly strong in muscle relative to androgenic tissues.

Why 322:24 Selectivity?

Oxandrolone's selectivity comes from tissue-specific differences in its AR transactivation profile. In androgen-sensitive tissues like prostate and skin, oxandrolone shows relatively weak activity. In skeletal muscle, it drives protein synthesis through AR-mediated gene programs with high efficiency. The 2-oxa modification may contribute to this tissue selectivity through altered coactivator recruitment.

Hepatotoxicity Comparison

All C17α-alkylated oral AAS are hepatotoxic to varying degrees. Oxandrolone is considered relatively mild compared to Dianabol and Anadrol due to its predominantly renal excretion (unlike other 17α-AA which undergo extensive hepatic processing), but hepatic monitoring remains relevant in liver research models.

// Research Applications

Research Applications

  • Anabolic selectivity: 322:24 ratio — best-in-class model compound for selective AR activation in muscle vs androgenic tissues
  • DHT derivative pharmacology: 2-oxa modification effects on AR binding, transactivation, and tissue selectivity
  • Muscle wasting models: Oxandrolone's anabolic effect on muscle protein synthesis in cachexia and sarcopenia research
  • Burns research: Oxandrolone is FDA-approved for weight maintenance post-burn injury — mechanistic research applications
  • Non-aromatizing AAS: Pure AR anabolic effects without estrogenic contributions
  • Hepatic vs renal metabolism: Oxandrolone's predominantly renal excretion (unique among 17α-AA) for metabolic comparison studies
  • Bone density: AR-driven osteoblast activity without estrogen co-activation
  • Pediatric/GHD models: Oxandrolone used historically in pediatric growth research
// QSC Peptides Products

Buy Anavar from QSC Peptides

Research-grade · ≥99% purity · COA · Free USA USPS/FedEx · US domestic warehouse

Oral Anavar
Anavar 50mg Tablets | 100-Count
Oxandrolone · DHT Derivative · 322:24

QSC Peptides · ≥99% purity

≥99% Pure · COA
// FAQ

Frequently Asked Questions

Anavar is oxandrolone — a DHT-derived oral AAS with a 2-oxa A-ring modification. 322:24 anabolic:androgenic ratio — 3.22× the anabolic selectivity of testosterone with only 24% of the androgenic activity. No aromatization. C17α-alkylated for oral bioavailability. ~9 hour half-life. QSC Peptides offers 50mg tablets.
Oxandrolone shows tissue-selective AR transactivation — strong anabolic activity in skeletal muscle with weaker activity in androgenic tissues (prostate, skin). The 2-oxa modification alters the receptor-bound conformation and coactivator recruitment, producing tissue selectivity not seen with testosterone or nandrolone.
As a C17α-alkylated oral steroid, oxandrolone does cause some hepatic stress. However, it is generally considered less hepatotoxic than Dianabol or Anadrol, partly due to its predominantly renal (rather than hepatic) excretion route — a useful distinction in liver research models.
Yes. Free USPS/FedEx from US domestic warehouse on all orders.
// Related Compounds

Related AAS Research Compounds

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Anadrol
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Testosterone
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